{"id":4135,"date":"2018-12-21T15:58:17","date_gmt":"2018-12-21T15:58:17","guid":{"rendered":"https:\/\/cnls.sn\/?post_type=nos_actualites&p=4135"},"modified":"2018-12-21T15:58:17","modified_gmt":"2018-12-21T15:58:17","slug":"sida-des-chercheurs-de-linstitut-pasteur-ont-reussi-a-detruire-des-cellules-infectees","status":"publish","type":"post","link":"https:\/\/cnls.sn\/?p=4135","title":{"rendered":"Sida : des chercheurs de l’Institut Pasteur ont r\u00e9ussi \u00e0 d\u00e9truire des cellules infect\u00e9es"},"content":{"rendered":"

Des chercheurs de l’Institut Pasteur annoncent jeudi 20 d\u00e9cembre avoir r\u00e9ussi \u00e0 d\u00e9truire des cellules infect\u00e9es par le VIH. Leurs travaux, publi\u00e9s dans la revue scientifique Cell Metabolism, ne\u00a0repr\u00e9sentent pas \u00e0 ce jour une perspective\u00a0de traitement, mais un espoir vers une gu\u00e9rison des malades <\/em><\/p>\n

Aujourd’hui, le traitement du sida se fait gr\u00e2ce aux antir\u00e9troviraux, d\u00e9couverts dans les ann\u00e9es 1990 et utilis\u00e9s pour bloquer l’infection, mais ils n’\u00e9liminent pas le VIH<\/span> de l’organisme. Les malades doivent prendre leur traitement \u00e0 vie car ces m\u00e9dicaments ne permettent pas de d\u00e9truire les r\u00e9servoirs du virus, log\u00e9s dans les cellules immunitaires, les lymphocytes T\u00a0CD4.<\/p>\n

Emp\u00eacher l’infection des cellules<\/strong><\/p>\n

Les chercheurs ont remarqu\u00e9 que le virus n’infectait pas tous ces lymphocytes T\u00a0CD4<\/span> et, jusqu’ici, ils ne comprenaient pas pourquoi. Dans cette \u00e9tude, ils sont parvenus \u00e0 identifier les caract\u00e9ristiques des lymphocytes T\u00a0CD4 qui se font pr\u00e9f\u00e9rentiellement infecter par le virus, et dont l’activit\u00e9 m\u00e9tabolique permet au virus de se propager.<\/p>\n

Ces cellules ont la particularit\u00e9 de consommer davantage de glucose pour produire de l’\u00e9nergie. Les exp\u00e9riences ont montr\u00e9 que plus l’activit\u00e9 m\u00e9tabolique de la cellule est forte, plus sa consommation en glucose est \u00e9lev\u00e9e, et plus elle est susceptible d’\u00eatre infect\u00e9e par le VIH. D’o\u00f9 l’id\u00e9e des scientifiques de bloquer l’activit\u00e9 de ces lymphocytes, ceux qui se font pr\u00e9f\u00e9rentiellement infecter par le virus. Quand leur activit\u00e9 est bloqu\u00e9e, ces cellules r\u00e9sistent \u00e0 l’infection et, \u00e0 terme, cela permet d’\u00e9liminer le VIH<\/span>. En laboratoire, les lymphocytes sont parvenus \u00e0 bloquer l’infection gr\u00e2ce \u00e0 des inhibiteurs d’activit\u00e9 m\u00e9tabolique, d\u00e9j\u00e0 explor\u00e9s en canc\u00e9rologie.<\/p>\n

Ces travaux repr\u00e9sentent un pas important vers la consid\u00e9ration d\u2019une r\u00e9mission<\/span> possible gr\u00e2ce \u00e0 l\u2019\u00e9limination des cellules r\u00e9servoirs.Communiqu\u00e9 de l’Institut Pasteur.<\/p>\n

\u00ab\u00a0C’est une premi\u00e8re \u00e9tape int\u00e9ressante<\/span> mais nous ne sommes pas au stade o\u00f9 \u00e7a peut \u00eatre applicable \u00e0 l’homme dans un futur proche<\/span>. Il faut poursuivre les recherches et cette publication est un espoir suppl\u00e9mentaire\u00a0\u00bb<\/span><\/em> vers une gu\u00e9rison du sida, a r\u00e9agi sur franceinfo le sp\u00e9cialiste des maladies infectieuses et professeur \u00e0 l’h\u00f4pital Saint-Louis \u00e0 Paris, Jean-Michel Molina<\/strong>. Ces travaux \u00ab\u00a0sont extr\u00eamement importants car ils apportent des informations tout \u00e0 fait int\u00e9ressantes sur les cellules r\u00e9servoirs du virus qui, chez les personnes sous tri-th\u00e9rapie, persistent malgr\u00e9 le traitement, et qui obligent les personnes \u00e0 prendre le traitement toute leur vie.\u00a0\u00bb<\/em><\/p>\n

Les limites,<\/span> selon Jean-Pierre Molina, tiennent notamment au fait que les travaux ont \u00e9t\u00e9<\/span> \u00ab\u00a0men\u00e9s en laboratoire sur des cellules qui sont infect\u00e9es de fa\u00e7on artificielle par le virus<\/span>, m\u00eame si les r\u00e9sultats ont \u00e9t\u00e9 \u00e9galement observ\u00e9s sur des cellules de patients manipul\u00e9s en laboratoire.\u00a0\u00bb\u00a0\u00ab\u00a0\u00c7a laisse entrevoir des pistes int\u00e9ressantes\u00a0\u00bb,<\/em> assure-t-il, \u00ab\u00a0mais il va falloir confirmer, en laboratoire puis chez l’homme\u00a0\u00bb.<\/span> <\/em><\/p>\n

Avec France infos<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Des chercheurs de l’Institut Pasteur annoncent jeudi 20 d\u00e9cembre avoir r\u00e9ussi \u00e0 d\u00e9truire des cellules infect\u00e9es par le VIH. Leurs travaux, publi\u00e9s dans la revue scientifique Cell Metabolism, ne\u00a0repr\u00e9sentent pas \u00e0 ce jour une perspective\u00a0de traitement, mais un espoir vers une gu\u00e9rison des malades Aujourd’hui, le traitement du sida se fait gr\u00e2ce aux antir\u00e9troviraux, d\u00e9couverts[…]\n","protected":false},"author":14,"featured_media":4138,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[5],"tags":[],"class_list":["post-4135","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualite"],"yoast_head":"\nSida : des chercheurs de l'Institut Pasteur ont r\u00e9ussi \u00e0 d\u00e9truire des cellules infect\u00e9es - CNLS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cnls.sn\/?p=4135\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sida : des chercheurs de l'Institut Pasteur ont r\u00e9ussi \u00e0 d\u00e9truire des cellules infect\u00e9es - CNLS\" \/>\n<meta property=\"og:description\" content=\"Des chercheurs de l’Institut Pasteur annoncent jeudi 20 d\u00e9cembre avoir r\u00e9ussi \u00e0 d\u00e9truire des cellules infect\u00e9es par le VIH. 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