{"id":3828,"date":"2018-09-28T11:56:10","date_gmt":"2018-09-28T11:56:10","guid":{"rendered":"https:\/\/cnls.sn\/?post_type=nos_actualites&p=3828"},"modified":"2018-09-28T11:56:10","modified_gmt":"2018-09-28T11:56:10","slug":"vih-un-traitement-alternatif-aux-antiretroviraux-en-test","status":"publish","type":"post","link":"https:\/\/cnls.sn\/?p=3828","title":{"rendered":"VIH : un traitement alternatif aux antir\u00e9troviraux en test"},"content":{"rendered":"

Des traitements par anticorps administr\u00e9s \u00e0 plusieurs semaines d’intervalle remplacer ont-ils un jour la prise quotidienne d’antir\u00e9troviraux pour lutter contre le virus du sida ? Cette piste est explor\u00e9e par des chercheurs am\u00e9ricains, avec des r\u00e9sultats encourageants.<\/em><\/p>\n

Selon deux \u00e9tude<\/span>s publi\u00e9es mercredi\u00a0 26 Septembre 2018 dans les revues Nature et Nature Medicine,<\/span> des s\u00e9ropositifs ont \u00e9t\u00e9 trait\u00e9s par anticorps avec la m\u00eame efficacit\u00e9 qu’avec des antir\u00e9troviraux.<\/span> A la grosse diff\u00e9rence pr\u00e8s que cette solution \u00e9tait beaucoup moins contraignante<\/span> pour eux.<\/p>\n

\u00ab\u00a0Un traitement s\u00fbr et fiable bas\u00e9 sur des anticorps pourrait ouvrir de nouvelles perspectives aux personnes vivant avec le VIH (le virus du sida)\u00a0\u00bb,<\/span> a comment\u00e9 Anthony Farci, directeur de l’Institut national am\u00e9ricain des allergies et des maladies infectieuses (NIAID). Il juge que ces travaux, tr\u00e8s pr\u00e9liminaires, \u00ab\u00a0repr\u00e9sentent un premier pas important vers cet objectif\u00a0\u00bb.<\/span><\/p>\n

Antir\u00e9troviraux, des effets secondaires nombreux<\/strong><\/p>\n

Les antir\u00e9troviraux, m\u00e9dicaments apparus dans les ann\u00e9es 1990, ont r\u00e9volutionn\u00e9 la vie des s\u00e9ropositifs. Ils permettent de r\u00e9duire le virus \u00e0 un niveau ind\u00e9tectable et d’emp\u00eacher sa transmission. Mais ils doivent \u00eatre pris quotidiennement, \u00e0 vie, et pr\u00e9sentent des effets ind\u00e9sirables (diarrh\u00e9es, naus\u00e9es…).<\/p>\n

Dans les deux \u00e9tudes publi\u00e9es mercredi, les chercheurs ont recrut\u00e9 15 s\u00e9ropositifs trait\u00e9s par antir\u00e9troviraux.<\/span><\/p>\n

Ils ont arr\u00eat\u00e9 leur traitement et ont re\u00e7u \u00e0 la place des injections de deux anticorps. Ces derniers ciblent des prot\u00e9ines pr\u00e9sentes \u00e0 la surface du virus et utilisent le syst\u00e8me immunitaire du patient pour le combattre.<\/p>\n

Les anticorps utilis\u00e9s sont naturellement pr\u00e9sents dans l’organisme d’une cat\u00e9gorie rarissime de patients (moins de 1% du total) appel\u00e9s \u00ab\u00a0contr\u00f4leurs naturels\u00a0\u00bb. Leur corps arrive \u00e0 emp\u00eacher le VIH de se d\u00e9velopper sans jamais avoir pris de m\u00e9dicament, pour des raisons encore myst\u00e9rieuses.<\/p>\n

Apr\u00e8s l’injection initiale, les patients en ont re\u00e7u une autre au bout de trois semaines et une troisi\u00e8me au bout de six semaines.<\/span><\/p>\n

Selon les chercheurs, la charge virale des volontaires ainsi trait\u00e9s est rest\u00e9e ind\u00e9tectable pendant 15 semaines en moyenne, et m\u00eame 30 semaines pour deux d’entre eux.<\/span><\/p>\n

C’est un cocktail de deux anticorps qui a \u00e9t\u00e9 administr\u00e9 aux patients, pour amoindrir la r\u00e9sistance du virus, obstacle auquel des recherches similaires s’\u00e9taient heurt\u00e9es par le pass\u00e9.<\/p>\n

\u00ab\u00a0Cette technique a \u00e9t\u00e9 test\u00e9e par le pass\u00e9 avec des anticorps beaucoup moins puissants et qui n’\u00e9taient pas efficaces\u00a0\u00bb<\/span>, a expliqu\u00e9 \u00e0 l’AFP l’un des chercheurs, Michel Nussenzweig, immunologiste \u00e0 la Rochester University, aux Etats-Unis.<\/span><\/p>\n

\u00ab\u00a0Notre objectif, c’est de modifier ces anticorps pour augmenter encore leur dur\u00e9e d’action, afin que les patients puissent \u00eatre trait\u00e9s seulement \u00e0 quelques reprises dans l’ann\u00e9e<\/span> plut\u00f4t que devoir prendre des pilules tous les jours\u00a0\u00bb, a-t-il ajout\u00e9.<\/p>\n

Avec www.leprogres.fr<\/strong><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Des traitements par anticorps administr\u00e9s \u00e0 plusieurs semaines d’intervalle remplacer ont-ils un jour la prise quotidienne d’antir\u00e9troviraux pour lutter contre le virus du sida ? Cette piste est explor\u00e9e par des chercheurs am\u00e9ricains, avec des r\u00e9sultats encourageants. Selon deux \u00e9tudes publi\u00e9es mercredi\u00a0 26 Septembre 2018 dans les revues Nature et Nature Medicine, des s\u00e9ropositifs ont[…]\n","protected":false},"author":14,"featured_media":3829,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[5],"tags":[],"class_list":["post-3828","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualite"],"yoast_head":"\nVIH : un traitement alternatif aux antir\u00e9troviraux en test - CNLS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cnls.sn\/?p=3828\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"VIH : un traitement alternatif aux antir\u00e9troviraux en test - CNLS\" \/>\n<meta property=\"og:description\" content=\"Des traitements par anticorps administr\u00e9s \u00e0 plusieurs semaines d’intervalle remplacer ont-ils un jour la prise quotidienne d’antir\u00e9troviraux pour lutter contre le virus du sida ? 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